SUMMARY OF THE REMEDIATION TECHNOLOGIESDEVELOPMENT FORUM
IN-PLACE INACTIVATION AND NATURAL ECOLOGICAL RESTORATION
TECHNOLOGIES (IINERT) SOIL-METALS ACTION TEAM
BIOAVAILABILITY/BIOACCESSIBILITY SUBGROUP
CONFERENCE CALL

July 10, 1997


1.     Review TASKS 1 and 2

Everyone is asked to look over TASKS 1 and 2 and make any suggestions for changes to Bill Berti (DuPont) at bill.berti@usa.dupont.com. The next step is to more fully develop this part of the plan in conjunction with the other two subgroups.

2.    Build databases on all available in vivo and in vitro studies, including inplace inactivation treatment effects on bioavailability in animal models. Create an IINERT bibliography.

One way of accomplishing this may be to use the capabilities of our page on the World Wide Web (http://www.rtdf.org). Carolyn Perroni of EMS can help, but there are several details to work out.

The database references and bibliography should probably be limited to papers and reports that have undergone some level of review and/or are okay to make public knowledge. Because the World Wide Web is open and available to just about anyone in the world, there may be some sensitivity in posting preliminary data and works in progress. Also, individuals may have bibliographies that are extensive, but have taken years and quite a lot of effort to construct. It is unfair to suddenly make them public information.

As a start, a single bibliography, including the databases, would be organized around three areas: (1)bioavailability (using the toxicological meaning of the word--uptake by animals), (2)mobility (which includes plant uptake, leaching, runoff, and subjects on ecotoxicity), and (3)contaminant inactivation/ stabilization/ sequestration, including equipment that may be useful for performing inplace inactivation in the field. Contaminants and media would not be restricted to Pb in soil only.

For those who have reports and papers to include, please send author(s), year, title, source, keywords, which of the three areas it falls under (please choose only one of the categories if possible) and who to contact for a reprint (if necessary) to Carolyn at cperroni@emsus.com. Abstracts or short summaries can also be included, but there should not be any personal remarks about a paper. The purpose is not to develop an 'on-line' version of a report or paper, but to list important ones and where copies can be obtained or who to contact for more information.

Please use a standarized formatting such as that found in "Journal of Environmental Quality, Environmental Toxicology and Chemistry, and Fundamental and Applied Toxicology". As an example:

Berti, W.R., and S.D. Cunningham. 1997. In-place inactivation of Pb in Pb-contaminated soils. Environ. Sci. Technol. 31:1359-1364.
Keywords: soil-Pb, Toxicity Characteristic Leaching Procedure, Physiologically Based Extraction Test, sequential chemical extractions.
Cat. 3.
In-place inactivation reduces the hazards of contaminated soils through the use of materials that change the soil Pb chemistry.

This will help in a couple of ways:

Information should be provide to Carolyn in WordPerfect, MS Word, or as ASCII text. She will then organize them and post the bibliography and database references in the "Technical Documents" area of the team's web page. The area can be continually updated as new information is submitted. Someone is needed to be a point of contact for Carolyn on this job who will periodically review what's there and let her know if anything needs to be changed, deleted, etc. Any volunteers???

Please make comments and suggestions to Carolyn Perroni or Bill Berti.

3.    Develop a matrix of various animal models.

A matrix of the pros and cons of various animal models (pigs, primates, rats) to determine soil-contaminant bioavailability would be constructed. Mark Maddaloni has volunteer to make a first attempt to construct a matrix and then fill it in with the human dosing studies. Stan Casteel has volunteered to fill it in for swine models. The matrix will include the cost of a study (per soil???), time needed to complete study, something on surrogacy (what is the model trying to simulate?), contaminant(s) that the model can assess, limits of detection, ethical considerations, what is unique about a particular model, how can the information provided be used in helping to set clean-up standards or determine treatment efficacy, who should be contacted for more information, what are the important references, etc. At some point we may want to pass it around to others within and outside the group for more suggestions and comments. This may also be an opportunity to use the web page to facilitate the matrix development. EXCEL will be used to begin matrix construction.

Please make comments and suggestions to Mark Maddaloni at maddaloni.mark@epamail.epa.gov.

4.    Preliminary results of phosphorus effect in lab treatability studies on soil-Pb bioavailability measured using the swine model were reported by Stan Casteel.
Please contact Dr. Casteel for more information at casteel@vmdl.missouri.edu.

5.    Schedule regular conference calls for the group on the 2nd Thursday of each month at 1 pm. The next call will be August 14.